2026-04-14T05:03:56Z https://jcarr.in/index.php/files/oai

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oai:ojs2.jcarr.in:article/87 2025-12-15T10:01:07Z files:ART

Medicinal Effect of Curcumin as an Anti-tuberculosis Amruta Bapu Lokhande Ankit Raju Madhuri Bharat Yadav Anti–tubercular, Mycobacterium Since very early times, people have been afflicted by the disease known as tuberculosis (TB). Anti-TB allopathic drugs have been administered to manage the disease's symptoms, but they include side effects such hepatitis, hypersensitivity responses, nausea, and vomiting, among others. Ayurvedic (Indian traditional medicine) and foreign medicinal herbs origin have been used to treat TB with success. In this particular review, turmeric with potential anti-tubercular action were described. curcumin is the principal curcuminoid obtained from the plant curcuma longa and has been extensively studied for its biological and chemical properties, including antimicrobial, antiinflammatory, antioxidant, and antitumor activity. These include antimycobacterial activity, modulation of the host immune response and enhancement of BCG vaccine efficacy. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/87 10.62896/jcarr.v1.i1.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/87/40 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/88 2025-12-15T10:01:07Z files:ART

An Approach in Novel Drug Delivery Systems Future Prospects and Opportunities Upendra Prajapati Abhishek Prajapat Shaily Chaudhary Akash Yadav Novel drug delivery system, Phytosomes, Liposomes, Nanoparticles, Dosage forms. The term "novel drug delivery system" (NDDS) refers to techniques, formulations, technologies, and systems for conveying a pharmaceutical substance in the body as needed to safely achieve its targeted therapeutic effects. The Novel Drug Delivery System (NDDS) combines advanced techniques with a standard drug delivery system to deliver drugs in a different way. Compared to traditional dose forms, NDDS are a considerably superior new dosage form. The development of an existing therapeutic molecule from a traditional form to a unique delivery method can greatly increase its performance in terms of patient compliance, safety, and efficacy. Novel Drug Delivery System uses a variety of ways, such as medical devices or drug-device combo solutions. Designing such delivery systems is primarily done to reduce drug loss and degradation, avoid negative side effects, and boost bioavailability. New medication delivery methods are created based on biological and physical processes. Diffusion, osmosis, erosion, and dissolution are examples of physical mechanisms or controlled drug delivery systems. Nanoparticles, liposomes, gene therapy, and monoclonal antibodies are examples of biochemical mechanisms. Different drug targeting and delivery technologies are currently under development. This article covers the basic information regarding Novel Drug Delivery Systems Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/88 10.62896/jcarr.v1.i1.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/88/41 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/89 2025-12-15T10:01:07Z files:ART

Sweet Alyssum (Lobularia maritima): Medicinal Potential, Nurturing Techniques, and Ecological Significance - A Comprehensive Review Preeti Singh Lobularia maritima, medicinal potential, cultivation techniques, ecological significance. The plant known as sweet alyssum (Lobularia maritima) has important ecological, therapeutic, and agricultural potential. Antimicrobial, anti-inflammatory, and potentially anticancer actions are some of its therapeutic qualities. We go over how to cultivate it, what kind of soil to use, how to propagate it, and how to maximize the phytochemical content. In addition to encouraging biodiversity and ecological resilience, sweet alyssum is also utilized for soil enrichment, insect control, and pollinator attraction. Compatibility with specialized crops, potential as a cover crop, and long-term benefits to soil ecology are only a few of its agricultural uses. The ecological effects of the plant include improving water retention, promoting biodiversity, and aiding in the sequestration of carbon. Expanding cultivation for commercialization, optimizing traits through breeding programs, addressing gaps in the literature, and exploring multidisciplinary research topics are some of the future study goals. All things considered, the importance of sweet alyssum in sustainable agriculture, health care, and environmental preservation is emphasized. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/89 10.62896/jcarr.v1.i1.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/89/42 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/90 2025-12-15T10:01:07Z files:ART

Exploring Breast Cancer Liver Metastasis (BCLM): A Global Perspective on Symptoms, Risk Factors, and Geographical Variations Km. Bhumika Iram Rajpoot Km. Shiva Suraj Mandal Breast cancer liver metastasis, BCLM, breastfeed, Breast Cancer Research Breast cancer liver metastasis may cause cachexia, nausea, vomiting, anorexia, severe hepatomegaly, jaundice, and ascites. Breast cancer is the most frequent cancer in women and a killer. The sickness is widespread, although regional incidence, mortality, and survival rates differ. Environment, genetics, lifestyle, and population structure may produce these disparities. The study used English-language breast cancer risk factor and epidemiology literature. This analysis eliminated qualitative research, therapeutic and diagnostic studies, and studies that were not focused on the study's goals. Titles, abstracts, and full texts determined study selection. Breast cancer, the most prevalent cancer among women, ranks second worldwide. 12.4% of American women—1 in 8—will get breast cancer. In 2012, 1.67 million breast cancer cases were detected globally, 25% of all malignancies. Cancer may affect anybody, although industrialized countries have a higher risk, and breast cancer rates differ by race and ethnicity. More women globally have breast cancer than any other cancer. Worldwide, a million new cases and 400,000 fatalities were projected in 2002. Northern Europe and North America have the highest incidence, southern Europe and South America middle, and Africa and Asia lowest. Less industrialized countries have 20 age-standardized occurrences per 100,000, whereas developed ones have 95. Chinese women breastfeed for fewer months, have fewer children, and have their first child later in life than Malay women. High socioeconomic status, cuisine, and genetics may increase risk factors in China. The Breast Cancer Research Initiatives Foundation (CARIF) in Malaysia is exploring breast cancer genetics in Malaysian women owing to data shortages. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/90 10.62896/jcarr.v1.i1.04 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/90/43 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/92 2025-12-15T10:01:07Z files:ART

Innovations in Transdermal Drug Delivery: Strategies, Challenges and Future Directions Dhanshri Mahajan Akash Yadav Dinesh Kumar Jain TDDS, Strategies, Components, Functions, Systems Transdermal drug delivery systems offer an efficient and non-invasive means of administering therapeutic agents through the skin for systemic distribution. This approach bypasses the gastrointestinal tract, avoiding issues such as enzymatic degradation and first-pass metabolism, while offering sustained release and improved patient compliance. The skin's barrier properties, primarily the stratum corneum, present challenges for effective drug penetration, requiring the use of various enhancement strategies like chemical penetration enhancers, physical methods (e.g., iontophoresis, microneedles), and formulation technologies (e.g., nanoparticles, liposomes). Key factors influencing transdermal delivery include drug physicochemical properties, formulation design, and skin characteristics. Advancements in formulation technologies, coupled with an improved understanding of skin physiology and drug permeation mechanisms, continue to expand the application of transdermal delivery across various therapeutic areas, offering promising avenues for personalized medicine and enhanced patient care. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/92 10.62896/jcarr.v1.i1.05 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/92/44 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/93 2025-12-15T10:01:07Z files:ART

Diabetes Mellitus: Understanding the Pathophysiology and Therapeutic Strategies Anjali Gupta Akash Yadav Dinesh Kumar Jain Diabetes mellitus, Type 1 diabetes, Type 2 diabetes, Gestational diabetes, Hypoglycemia, Hyperglycemia Diabetes Mellitus (DM) affects approximately 100 million people worldwide, with both type 1 and type 2 diabetes causing significant health problems. Type 1 diabetes results from an autoimmune attack on pancreatic beta cells, resulting in inadequate insulin production; Type 2 diabetes is associated with insulin resistance and inadequate insulin secretion, which are mostly affected by genetics and lifestyle. Gestational diabetes also increases risk during pregnancy. Effective management requires lifestyle changes, medication, and sometimes insulin therapy. Complications include heart problems, kidney disease, neuropathy and eye problems. Many factors such as genetics, lifestyle and environmental factors can affect the development of diabetes. It is important to understand the pathophysiology of diabetes, including the role of insulin and glucagon. Lifestyle changes such as healthy eating, exercise and weight control are important. Pharmacological interventions, including insulin therapy and oral medications, are tailored to individual needs. Research is constantly exploring new avenues for future treatments, such as stem cells and gene therapy. Management strategies that integrate healthcare, lifestyle, and education are critical to reducing the burden of diabetes and improving patient outcomes. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/93 10.62896/jcarr.v1.i1.06 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/93/45 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/94 2025-12-15T10:01:07Z files:ART

Unveiling the Digital Frontier: Technological Advances in Pharmacy Research Sonal Akhand Akash Yadav Dinesh Kumar Jain Digital technologies, health 4.0, artificial intelligence, mobile health, ehealth This paper explores the transformative impact of digital technologies on the pharmaceutical sector in Europe and America, alongside Bulgaria's initiatives to address challenges such as counterfeit medicines and communication gaps through e-prescriptions and health information platforms. Focusing on drug therapy management, pharmacogenomics, 3D printing of medicines, and personalized care, it highlights how digital innovations are revolutionizing efficiency and patientoutcomes. Through survey analyses and pharmacist questionnaires, the paper investigates the acceptance and attitudes of German society toward digital health solutions, providing insights into their adoption within pharmacies. With the total number of pharmacies declining amidst a growing healthcare sector, the study underscores the importance of integrating efficient digital technologies to improve customer experience and maintain competitiveness. By offering actionable recommendations for pharmacies to embrace digitalization and navigate the transition to digital markets, this paper serves as a valuable roadmap for industry stakeholders, ensuring their continued success and relevance in the evolving landscape of Health 4.0. Sujata Publications 2024-05-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/94 10.62896/jcarr.v1.i1.07 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/94/46 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/95 2025-12-15T10:01:07Z files:ART

Navigating Gastrointestinal Challenges: Unveiling Effective Approaches to Disease Management and Medicinal Solutions Nikita Patil Akash Yadav Dinesh Kumar Jain Constipation, Gastrointestinal disease, Heartburn, Irritable bowel syndrome, Ulcer This abstract provides a comprehensive overview of common gastrointestinal diseases, encompassing diagnostic approaches and treatment modalities. The diagnostic spectrum involves a triad of lab tests, imaging studies, and endoscopic procedures tailored to each ailment. Lab tests encompass Fecal occult blood test and Stool culture, while imaging tests incorporate advanced technologies like Magnetic resonance imaging (MRI) and CT scans. Endoscopic procedures, such as Colonoscopy and Esophagogastroduodenoscopy, play a pivotal role in visualizing and diagnosing gastrointestinal conditions. Treatment strategies emphasize a holistic approach, incorporating balanced diets, adequate hydration, and stress management. Regular check-ups are pivotal for monitoring disease progression and adjusting treatment plans accordingly. Lifestyle modifications, such as avoiding tobacco and excessive alcohol consumption, are integral components of disease management. This abstract underscore the multifaceted nature of gastrointestinal diseases, advocating a comprehensive strategy for diagnosis and management. Sujata Publications 2024-06-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/95 10.62896/jcarr.v1.i1.08 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/95/47 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/96 2025-12-15T10:01:07Z files:ART

Precision Pharmacotherapy: Unveiling the Types, Necessity and Application of Targeted Drug Delivery Pranay Kurariya Akash Yadav Dinesh Kumar Jain Liposomes, Niosomes, Electrosomes, Virosomes, Phytosomes. Targeted drug delivery systems have emerged as a promising approach to enhance the efficacy and reduce the side effects of therapeutic agents. The primary objective of targeted drug delivery systems is to selectively deliver therapeutic agents to specific sites within the body, such as tumours or inflamed tissues, while minimizing systemic exposure. This is achieved through the incorporation of targeting ligands, such as antibodies, peptides, or small molecules, which can recognize and bind to specific receptors or biomarkers expressed on the surface of target cells. These systems offer advantages such as improved pharmacokinetics, prolonged circulation time, and enhanced cellular uptake. Additionally, they can be engineered to respond to stimuli present in the microenvironment of diseased tissues, allowing for controlled drug release at the target site. The article also highlights recent developments in the field, such as the use of nanotechnology for precise drug delivery, the application of gene editing techniques for targeted therapy, and the integration of imaging modalities for real-time monitoring of drug delivery. Sujata Publications 2024-06-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/96 10.62896/jcarr.v1.i1.09 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 1, June 2024 3048-6556 eng https://jcarr.in/index.php/files/article/view/96/48 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/106 2025-12-15T10:07:29Z files:ART

Formulation and Evaluation of herbal mosquito Repellent cream using Tagetes erecta L. & Mentha piperita L. Akash Kumar*, Mohit Sharma, Neelam Dhankhar Mosquito, Mentha Piperita, Insecticidal, Repellency, Dermatological, Essential oil Mosquito-borne diseases are a significant public health concern worldwide. The use of synthetic insecticides for mosquito control has led to various drawbacks, including the development of resistance, environmental pollution, and adverse effects on human health. Therefore, there is a growing interest in developing natural and eco-friendly alternatives, such as plant-based mosquito repellents. Tagetes erecta L. (marigold) and Mentha piperita L. (peppermint) are two promising plants with potential mosquito repellent properties. The objective of this study is to formulate and evaluate a herbal mosquito repellent cream using the essential oils of T. erecta and M. piperita. The cream formulation is expected to provide a convenient and effective way to deliver the repellent activity of these plants, while ensuring good stability and sensory properties. Sujata Publications 2024-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/106 10.62896/jcarr.v1.i2.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 2, September 2024; 01-07 3048-6556 eng https://jcarr.in/index.php/files/article/view/106/49 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/107 2025-12-15T10:07:29Z files:ART

Unravelling the Complexity of Hypertension: Mechanism, Management and Beyond Mohini Rithoriya, Akash Yadav*, Dinesh Kumar Jain Hypertension, Resistance Hypertension, Blood Pressure, Epidemiology, pathophysiology Hypertension, commonly known as high blood pressure, is a significant global health concern affecting millions worldwide. This review aims to provide a comprehensive understanding of hypertension, including its epidemiology, etiology, pathophysiology, diagnosis, and management strategies. Epidemiologically, hypertension is widespread, with prevalence rates varying across different demographic groups. It is a multifactorial condition influenced by genetic predisposition, lifestyle factors, and comorbidities such as diabetes and obesity. The pathophysiology of hypertension involves complex interplays between vascular, renal, neural, and hormonal mechanisms, leading to increased peripheral vascular resistance and cardiac workload. Diagnosis of hypertension relies on accurate blood pressure measurement and classification based on established guidelines. Lifestyle modifications, including dietary changes, regular exercise, and stress management, form the cornerstone of non-pharmacological management. However, pharmacotherapy becomes necessary for many individuals to achieve target blood pressure levels and reduce cardiovascular risks. Various classes of antihypertensive medications, including diuretics, beta-blockers, ACE inhibitors, angiotensin receptor blockers, calcium channel blockers, and others, are available, with selection guided by individual patient characteristics and comorbidities Additionally, hypertension management encompasses addressing associated risk factors such as dyslipidaemia and implementing strategies for secondary prevention of complications like stroke, myocardial infarction, and renal dysfunction. Sujata Publications 2024-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/107 10.62896/jcarr.v1.i2.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 2, September 2024; 08-18 3048-6556 eng https://jcarr.in/index.php/files/article/view/107/50 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/108 2025-12-15T10:46:42Z files:ART

Comprehensive Review on HIV: Unravelling Its History, Virology, Epidemiology, Sociobehavioral Dynamics with Focus on Challenges, Impact of Covid-19, Novel Treatments, and Emerging Research Trends and Current Research Shashank Tiwari Preet Patel Kirti Singh Shreya Verma Kartikay Prakash Human Immunodeficiency Virus, HIV, Virology, Pathogenesis, Current research, FDA approved novel drugs. This review aims to provide a comprehensive virology and pathogenesis of HIV, the epidemiological landscape, challenges in diagnosis and treatment, Herbal Treatment, FDA approved Novel Drug for the Treatment of HIV and the socio-behavioral aspects affecting prevention and care, and promising directions in research, including vaccine development and potential eradication strategies. By consolidating insights from diverse fields, this review intends to contribute to a deeper understanding of HIV and its multifaceted impacts, aiming to inform future directions for research, policy, and public health interventions. Sujata Publications 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/108 10.62896/jcarr.v1.i2.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 2, September 2024; 19-29 3048-6556 eng https://jcarr.in/index.php/files/article/view/108/51 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/111 2025-12-15T10:33:31Z files:ART

Precision Medicine and Targeted Therapies in Oncology: Advancements in Drug Discovery and Clinical Applications Namrata Bhutani Bhavit Bansal Soumik Chatterjee Evana Raj Asutosh Pradhan Cancer types, targeted treatment, patient outcomes, treatment side effects, insurance coverage, access to treatment, lung cancer, breast cancer, colorectal cancer, treatment response. Aim: Evaluation of the frequency of different cancer kinds, evaluation of patient responses to targeted treatments, analysis of treatment-related side events, and investigation of the influence of insurance coverage on access to these medicines are the objectives of this research. Purpose: The goal is to comprehend patient side effects, the efficacy of targeted medicines, and the function of insurance in facilitating treatment access. The purpose of this study is to provide insights that help improve patient outcomes and therapy for cancer. Method: A descriptive cross-sectional technique was used to assess 200 cancer patients who were undergoing targeted treatment. Standardized questionnaires were used to gather information on the different types of cancer, treatment outcomes, side effects, insurance coverage status, and demographics. Result: Key data showed that the most common cancer was lung cancer (20%), which was followed by colorectal cancer (15%) and breast cancer (17.5%). In response to treatment, 15% had a full response, 30% had a partial response, 35% stayed stable, and 20% saw their condition advance. Fever (20%), nausea (25%), and hair loss (15%) were among the adverse effects. In terms of insurance, 10% were uninsured, 40% had limited coverage, and 50% had complete coverage. Conclusion: The research emphasizes the significance of insurance coverage, the variety of therapy responses, and the intricacies of cancer treatment in precision medicine. To enhance therapeutic approaches and provide better access to vital therapies, which will ultimately improve patient care overall, more research is required. Sujata Publications 2024-10-21 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/111 10.62896/jcarr.v1.i2.04 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 2, September 2024; 30-40 3048-6556 eng https://jcarr.in/index.php/files/article/view/111/52 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/112 2025-12-15T11:04:07Z files:ART

Herbal Extraction, Characterization and Evolution of Film Coating by Natural Polymer Trigonella Foenumgraceum L. (Methi) Ritu Verma Priya Bharti Amit Singh Garima Gupta Mohd Shuaib Ambika Shakya Natural polymer, trigonella foenumgraceum L (methi), solvent casting technique Nowadays' home grown (normal) items are more utilized than to artificially engineered items as a result of they have low harmfulness, biocompatibility, less expensive and biodegradable. We attempting to plan and portray buccal movies of glimepiride by utilizing the normal polymer, the regular polymer were extricated from seeds of trigonella foenumgraceum L (methi). Dissolvable extraction strategy was utilized for extraction and was portrayed for various boundaries i.e., pH, expanding file, Carr's list, tapped thickness, mass thickness, actual attributes, and point of rest. It was observed that the adhesive was insoluble in cool water however dissolvable in steaming hot water with various dissolvable. The buccal movies were formed utilizing dissolvable projecting method. The principal polymer utilized was Methi adhesive polymer. Various centralizations of polymer were utilized in the advancement of buccal film. The planned movies were assessed for various boundaries like deterioration, enlarging record, elasticity, surface pH, and weight consistency, in vitro drug discharge, drug content, thickness and collapsing perseverance. pH of the figured out films was between 6.5 to 7.5. The medication content of movies was in the scope of 7.3-9.3. In vitro drug discharge study showed a typical 84% medication discharge from every one of the figured out films up to 6 hrs. Expanding record of the planned movies showed great ballooning to 2 hrs. It was seen that Plan F4 was the best detailing out of all definitions. In the entire bunch the polymer focus was 300 mg/25 ml. The buccal movies of glimepride were ready by dissolvable projecting method. Sujata Publications 2024-10-24 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/112 10.62896/v1.i3.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 3, December 2024; 1-9 3048-6556 eng https://jcarr.in/index.php/files/article/view/112/53 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/113 2025-12-15T10:07:29Z files:ART

Analytical Method Development and Validation of Thioridazine by RP-HPLC method Rucha M. Chopade, Priyanka S. Patil, Nikita U. Dhake, Mohini V. Kshirsagar, Vaishnavi R. Mankar, Pranita A. Thakre, Vinayak M. Shejol Thioridazine, RP-HPLC, Validation. Method development and validation are extremely important in the development of drug material. For many drug products, Scientists working on Investigational New Drug (IND), New Drug Application (NDA), and Abbrevated New Drug Application (ANDA) used to characterized API’S and excipients have not been sufficiently developed or validated 1,2. The objective of the present study is to establish and generate inheriting Validation data for Thioridazine RP-HPLC method. Sujata Publications 2024-11-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/113 10.62896/jcarr.v1.i3.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 3, December 2024; 10-19 3048-6556 eng https://jcarr.in/index.php/files/article/view/113/54 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.literaryvoiceglobal.in:article/114 2024-12-14T15:22:59Z files:ART

oai:ojs2.jcarr.in:article/116 2025-12-15T10:07:29Z files:ART

Phytopharmaceuticals and Drug Development: Leveraging Natural Products for the Discovery of Novel Therapeutic Agents Vivek Jain Phytopharmaceuticals, Natural products, Drug development, Standardization, Bioavailability. Natural products have served as a cornerstone of drug discovery for centuries, offering a vast array of bioactive compounds with therapeutic potential. Among these, phytopharmaceuticals, derived from plant-based sources, stand out as a bridge between traditional medicine and modern pharmacology. These formulations are not crude extracts but standardized, quality-controlled products that meet stringent pharmaceutical criteria. This chapter delves into the role of phytopharmaceuticals in contemporary drug development, highlighting their contributions to treating diseases such as cancer, infections, and inflammatory disorders. It also addresses key challenges, including standardization, bioavailability, and regulatory compliance, while exploring innovative strategies like biotechnology, nanotechnology, and omics sciences to enhance their therapeutic value. By showcasing successful examples and emerging trends, this chapter underscores the transformative potential of phytopharmaceuticals in shaping the future of healthcare and drug discovery. Sujata Publications 2024-12-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/116 10.62896/jcarr.v1.i3.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 3, December 2024; 20-27 3048-6556 eng https://jcarr.in/index.php/files/article/view/116/56 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/117 2025-12-15T10:07:29Z files:ART

Current Status: Carbonic Anhydrase Inhibitors as Potential Alzheimer consequences Triloki Prasad*, Mohd. Shauib, Rohit Kumar, Deepak Kushwaha, Pradip Kumar, Preeti, Ambika Shakya, Vivek Kushwaha Alzheimer disease, AD, Carbonic anhydrase, Amyloid‐β (Aβ), N‐methyl‐D‐aspartate (NMDA) antagonist Alzheimer's illness (Promotion) is a neurodegenerative problem and a vital premise of dementia in the old populace worldwide. As of late, human carbonic anhydrases were exhibited as conceivable new focuses for treating Promotion. Expansion in the occurrence of neurodegenerative illnesses, specifically Alzheimer's Sickness (Promotion), is a result of the world′s populace maturing yet sadly, existing therapies are just compelling at deferring a portion of the side effects and temporarily. Regardless of enormous endeavors by both scholarly analysts and drug organizations, no illness adjusting drugs have been brought to the market somewhat recently. As of late, a few examinations shed light on Carbonic Anhydrases as conceivable new focuses for Promotion treatment. In the current survey we summed up preclinical and clinical discoveries with respect to the job of CAs and their inhibitors/activators on cognizance, maturing and neurodegeneration and we examine future difficulties and open doors in the field. Sujata Publications 2024-12-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/117 10.62896/jcarr.v1.i3.04 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 1, Issue 3, December 2024; 28-33 3048-6556 eng https://jcarr.in/index.php/files/article/view/117/57 Copyright (c) 2024 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.literaryvoiceglobal.in:article/120 2025-01-12T07:48:30Z files:ART

oai:ojs2.literaryvoiceglobal.in:article/121 2025-01-12T10:24:10Z files:ART

oai:ojs2.jcarr.in:article/122 2025-12-15T10:07:29Z files:ART

Total Knee Arthroplasty in a Stiff Knee Post Infection - A Case Report Aashish Chaudhry, Aakarsh Mahajan*, Sandeep Chauhan, Namita Sharma, Ishan Bhatia Arthroplasty, Knee arthrodesis, Periprosthetic joint infection (PJI), Stiff knee, Total Knee Arthroplasty (TKA), Constrained hinge implant, Ligament release. Purpose: This case report highlights the successful case of a fused knee to a functional joint through total knee arthroplasty (TKA) using a constrained hinge prosthesis in a 72-year-old male with a history of post-infectious ankylosis. Background: The patient developed septic arthritis following a platelet-rich plasma (PRP) injection, necessitating multiple debridements and long-term antibiotic therapy. Despite infection resolution, he experienced persistent stiffness, pain, and a minimal range of motion with knee (ROM) of 0–10°. Methods: Extensive preoperative planning confirmed the absence of infection and prepared for the challenges of fibrosis and bone deformity. The surgery utilized a medial parapatellar approach with extensive soft tissue release and constrained hinge prosthesis implantation. Outcomes: An intraoperative ROM of 0–90° was achieved, with postoperative radiographs confirming proper prosthetic alignment and fixation. Early rehabilitation helped maintain mobility, and no complications were observed in the early recovery phase. Conclusion: This report demonstrates the viability of constrained hinge prostheses in addressing complex cases of post-infectious knee ankylosis, emphasizing the importance of multidisciplinary care, meticulous planning, and early rehabilitation for favorable outcomes. Sujata Publications 2025-01-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/122 10.62896/jcarr.v2.i1.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 1-15 3048-6556 eng https://jcarr.in/index.php/files/article/view/122/60 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/123 2025-12-15T10:07:29Z files:ART

A Review on Wound Healing Activity of Daucus Carrota and General Method of Herbal Topical Formulation Shreyasi*, Anil Sharma, Shailesh Sharma, Hansraj Bishnoi, Amit Kumar Sharma Herbal plant, Herbal medicine, wound healing, Herbal formulation, Daucus carrota. Throughout much of human history, plants have served as the basis for medical treatments; this type of traditional medicine is still commonly used today. Herbal products that were once used in traditional medicine have gained popularity. Herbal medications play a significant role in both treating and preventing human illness all over the world. Herbal remedies often have the following benefits: efficacy, safety, acceptance, and affordability. Phytochemicals, sometimes referred to as bioactive substances, are abundant in fruits and vegetables and have become recognised for their nutraceutical and health beneficial properties. Daucus carota L. is used in the traditional medicine for the treatment of variety of ailments such as anti-oxidant, anti-inflammatory, anti-microbial, anti-cancer etc. Now a days herbal medicines are mostly administered from topical rout for various treatment purpose so aim of current review is described about wound healing activity of daucus carrota and general method of herbal topical formulation. Sujata Publications 2025-01-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://jcarr.in/index.php/files/article/view/123 10.62896/jcarr.v2.i1.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 16-22 3048-6556 eng https://jcarr.in/index.php/files/article/view/123/61 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/125 2025-12-15T10:07:29Z files:ART

The Interflow of Traditional Drug & Innovations as fundamental Drug Design Sarita Prajapati, Mohd. Shuaib, Fariha Parveen, Nitin Kumar, Priyanka, Nazim Khan, Sachin Kumar Yadav, Triloki Prasad*, Aslam Phytochemicals, natural products, traditional medicine Traditional medicines form the integral part of the health care system for the developing countries serving around 80% of the world population and are widely used as over the counter medication. There is urgent need to classify the traditional medicines to research facilitate utilization data, safety and efficacy data, quality control measures and provide new avenues for further drug research. Medical texts of Ayurveda have classified the herbs as per their therapeutic indication, but these texts are in Sanskrit or in regional language. This makes it difficult for researchers all over world to access, understand and interpret information. Thus this innovative approach of classification can serve as one stop source of all recent updated information on the herbal drug research for the academia and industry both.  Phytochemicals have a long and successful history in drug discovery. Sujata Publications 2025-03-08 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/125 10.62896/jcarr.v2.i1.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 23-27 3048-6556 eng https://jcarr.in/index.php/files/article/view/125/62 https://jcarr.in/index.php/files/article/view/125/63 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/126 2025-12-15T10:07:29Z files:ART

Harnessing AI for the Future of Pharma Manufacturing Archana Pattanaik*, Souvik Giri, Debashish Mohanty, Nilima Shukla Artificial intelligence, Innovative manufacturing, Automation, Drug development. Artificial Intelligence (AI) is making significant changes in numerous healthcare sectors around the world. Being an essential component of healthcare, the pharmaceutical industry is also not behind in utilizing AI’s vital role at various phases of the drug development process. Specifically, AI can be utilized at various stages of pharmaceutical research and manufacturing starting from drug discovery to several tasks involved in manufacturing operations ranging from quality control to packaging, including product tracking from beginning to end. AI plays a vital role in enhancing the complex manufacturing of biopharmaceuticals by optimizing processes in real time, monitoring cell health, and employing predictive analytics. By improving visibility, efficiency, and compliance, AI can lead to smarter manufacturing processes, superior quality products and efficient supply chain solutions. In addition, AI has a critical role to play in achieving temperature-controlled distribution of biopharmaceuticals, supply chain management, prediction of potential issues and patient-focused solution creations helpful in personalized medicine. However, there are still several challenges that need to be addressed before fully integrating AI into manufacturing operations at all levels. This article reviews the potential of AI in pharmaceutical manufacturing, highlighting its benefits, recent breakthroughs and major challenges in its full implementation. The article also discusses the prospects of AI and suggests solutions to overcome real time limitations associated with full implementation of an AI-integrated pharmaceutical manufacturing and research efforts within the industry and academic settings. Sujata Publications 2025-03-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/126 10.62896/jcarr.v2.i1.04 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 28-39 3048-6556 eng https://jcarr.in/index.php/files/article/view/126/64 https://jcarr.in/index.php/files/article/view/126/65 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/127 2025-12-15T10:07:29Z files:ART

The Impact of Climate Change on Infectious Diseases in Urban Areas: A Comprehensive Review Batchalakuri Rishitha, Boppana Tarun Bhaskhar* Climate, Infectious Disease, Urban Areas Urban areas, characterized by high population density, interconnected infrastructure, and socioeconomic disparities, are particularly vulnerable to the amplified effects of climate change. The altered climatic conditions, including increased temperatures, extreme precipitation events, and sea-level rise, significantly impact the transmission dynamics of infectious diseases. This review synthesizes current literature to explore the multifaceted relationship between climate change and infectious disease emergence and spread in urban settings. We examine the specific impacts on vector-borne, waterborne, foodborne, and zoonotic diseases, considering the unique urban context. Furthermore, we discuss the challenges in disease surveillance, modeling, and adaptation strategies, highlighting the need for integrated, multidisciplinary approaches to mitigate the health risks posed by climate change in urban environments. Sujata Publications 2025-03-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/127 10.62896/jcarr.v2.i1.05 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 40-54 3048-6556 eng https://jcarr.in/index.php/files/article/view/127/66 https://jcarr.in/index.php/files/article/view/127/68 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/128 2025-12-15T10:07:29Z files:ART

Enhancing Pharmacovigilance and Drug Safety Monitoring: Trends, Challenges, and Future Directions in Global Healthcare Systems Adusumalli Jathin Shyam Pharmacovigilance, adverse drug reactions (ADRs), drug safety, artificial intelligence, machine learning. Pharmacovigilance has become an essential pillar of modern healthcare, aiming to monitor, detect, and prevent adverse drug reactions (ADRs). The rapid evolution of pharmaceuticals—including biologics, precision medicine, and complex drug formulations—has necessitated a shift from traditional post-marketing surveillance to data-driven, real-time monitoring systems. Advanced technologies such as artificial intelligence (AI), machine learning (ML), blockchain, and real-world evidence (RWE) have emerged as crucial tools in pharmacovigilance, improving ADR signal detection, regulatory compliance, and patient safety. However, despite these advancements, challenges persist, including underreporting of ADRs, fragmented regulatory frameworks, data privacy concerns, and disparities in global pharmacovigilance infrastructure. This paper explores the current trends, key barriers, and future strategies for strengthening pharmacovigilance. By analyzing data from the World Health Organization (WHO), U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA), and peer-reviewed studies, this review highlights the role of AI-driven pharmacovigilance, big data analytics, patient-centered reporting mechanisms, and pharmacogenomics in enhancing drug safety. The study ultimately underscores the need for harmonized global regulations, increased healthcare professional engagement, and integration of emerging digital health solutions to build a proactive and resilient pharmacovigilance system worldwide. Sujata Publications 2025-03-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/128 10.62896/jcarr.v2.i1.06 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 55-67 3048-6556 eng https://jcarr.in/index.php/files/article/view/128/69 https://jcarr.in/index.php/files/article/view/128/70 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/129 2025-12-15T10:07:29Z files:ART

Knowledge and Practice of Artificial Intelligence Among Medical Students and Healthcare Professionals Kamma Poojitha Ram*, Chevuri Sandeep Artificial intelligence (AI), healthcare, diagnostic accuracy, cross-sectional survey Artificial intelligence (AI) is transforming healthcare by enhancing diagnostic accuracy, treatment planning, and patient management. However, the knowledge and practical application of AI among medical students and healthcare professionals remain variable. This study assesses the awareness, knowledge, and utilization of AI in healthcare among medical students and practitioners. A cross-sectional survey was conducted, and the findings highlight the current understanding of AI, barriers to its adoption, and recommendations for integrating AI education into medical curricula and professional training. Sujata Publications 2025-03-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/129 10.62896/jcarr.v2.i1.07 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 68-71 3048-6556 eng https://jcarr.in/index.php/files/article/view/129/71 https://jcarr.in/index.php/files/article/view/129/72 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/130 2025-12-15T10:07:29Z files:ART

Efficacy of Sodium Bicarbonate in Hyperkalemia-Induced Cardiac Arrest: A Retrospective Analysis Dandolu Tejaswi, Kamma Poojitharam*, Chevuri Sandeep Hyperkalemia, reversible cause, cardiac arrest, Sodium bicarbonate Hyperkalemia is a critical, reversible cause of cardiac arrest requiring immediate intervention. Sodium bicarbonate is widely used in emergency settings to manage metabolic acidosis and promote intracellular potassium shifting. However, its efficacy in improving survival rates in hyperkalemia-induced cardiac arrest remains a subject of debate. This retrospective study analyzes data from 100 patients to assess the impact of sodium bicarbonate administration on resuscitation outcomes, electrolyte correction, and overall survival. Sujata Publications 2025-03-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/130 10.62896/jcarr.v2.i1.08 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 72-74 3048-6556 eng https://jcarr.in/index.php/files/article/view/130/73 https://jcarr.in/index.php/files/article/view/130/74 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/131 2025-12-15T10:07:29Z files:ART

Evidence-Based Management of Recurrent UTIs: From Diagnosis to Prevention Shefali Sengar, Swati Prakash, Shradha Bisht, Vishakha Jaiswal* Bacterial Virulence; Antimicrobial Resistance; Culture Diagnosis; Probiotics; Urogenital Health; Non-antibiotic prophylaxis Recurrent urinary tract infections (UTIs) result from a complex interaction between bacterial virulence and host factors, making effective diagnosis and treatment crucial. Cultures are essential for confirming recurrent UTIs, allowing for accurate diagnosis and the monitoring of antibiotic resistance patterns, which benefits both the individual patient and the broader community. Initial therapy for acute infections should follow the guidelines established by the Infectious Diseases Society of America (IDSA), considering regional antimicrobial resistance patterns to ensure effective treatment. Prevention strategies vary based on patient demographics and risk factors. Younger individuals may reduce their risk by avoiding spermicides, which can disrupt the vaginal microbiome, and by taking cranberry supplements, which may prevent bacterial adhesion to the bladder lining. In older patients, the use of topical oestrogen can help maintain urogenital mucosa integrity, while strategies like ensuring complete bladder emptying and staying well-hydrated are also important in preventing infections. For patients prone to recurrent infections, long-term antibiotic prophylaxis may be considered. This approach can reduce the frequency of UTIs, although it must be carefully tailored to avoid the development of antibiotic resistance. Overall, a combination of tailored acute treatment and preventive measures offers the best approach for managing recurrent UTIs and minimizing their impact on patient health and public health. Sujata Publications 2025-03-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/131 10.62896/jcarr.v2.i1.09 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 1, January-March 2025; 75-86 3048-6556 eng https://jcarr.in/index.php/files/article/view/131/75 https://jcarr.in/index.php/files/article/view/131/76 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/133 2025-12-15T10:07:29Z files:ART

Diastolic Dysfunction in Asymptomatic Type 2 Diabetes Mellitus Evaluated by Echocardiography: A Cross-Sectional Study of 50 Patients Satyadipsinh B. Zala, Maulikkumar K. Karpatiya*, Darsh G. Vaghani, Rajesh Sumple Type 2 Diabetes Mellitus, Diastolic Dysfunction, Echocardiography, E/A Ratio, HbA1c, Left Ventricular Function Background: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and evidence suggests that diabetic cardiomyopathy may initially manifest as diastolic dysfunction before any overt systolic abnormalities. This study was undertaken to evaluate left ventricular diastolic function in asymptomatic T2DM patients using echocardiographic parameters. Methods: A cross-sectional observational study was conducted on 50 asymptomatic, normotensive T2DM patients aged 30–70 years. Echocardiographic parameters including E/A ratio, isovolumetric relaxation time (IVRT), and deceleration time (DT) were assessed. Patients with known cardiovascular diseases or other systemic conditions affecting cardiac function were excluded. Results: Among 50 patients, 26 (52%) demonstrated diastolic dysfunction. Diastolic dysfunction was more prevalent in males (59.2%) compared to females (43.4%). Significant correlations were observed between diastolic dysfunction and increasing age, BMI, HbA1c levels, and duration of diabetes (p < 0.05). E/A ratio <1, IVRT >100 ms, and DT >200 ms were sensitive indicators of early diastolic dysfunction. Conclusion: Diastolic dysfunction is prevalent in asymptomatic T2DM patients and may precede systolic abnormalities. Echocardiographic screening is essential in early stages of diabetes to prevent long-term cardiovascular complications. Sujata Publications 2025-06-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/133 10.62896/jcarr.v2.i2.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 01-04 3048-6556 eng https://jcarr.in/index.php/files/article/view/133/77 https://jcarr.in/index.php/files/article/view/133/78 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/134 2025-12-15T10:07:29Z files:ART

Marchiafava-Bignami disease with rare Etiology: A Case Report Yash Rajan, Darsh Vaghani*, Kathrotiya Vishal, Sunil Kumar Marchiafava-Bignami disease, chronic alcoholism, Corpus callosum, Sandwich sign Marchiafava-Bignami disease is a rare disorder of demyelination or necrosis of the corpus callosum and adjacent subcortical white matter that occurs predominantly in malnourished alcoholics[1]. The course of the disease may be acute, subacute, or chronic and is marked by dementia, spasticity, dysarthria, and inability to walk. Patients may lapse into coma and die, survive for many years in a demented condition, or occasionally recover[2]. Lesions appear as hypodense areas in portions of the corpus callosum on computed tomography (CT) and as discrete or confluent areas of decreased T1 signal and increased T2 signal on magnetic resonance imaging (MRI)[3]. Alcohol abusers without liver disease, amnesia, or cognitive dysfunction show thinning of the corpus callosum at autopsy[4] and on MRI[5,6], suggesting that alcohol or malnutrition damages the corpus callosum commonly in the absence of the necrotic lesions of Marchiafava-Bignami disease. These findings raise the possibility that aggressive nutritional supplementation along with a reduction in drinking can prevent the development of Marchiafava-Bignami disease in alcohol abusers. Here, we present a case report of MBD diagnosed in a 60 year-old male who presented with gait instability and slurred speech, in an effort to highlight the importance of obtaining MRI in patients presenting with behavioural disturbance and neurological findings, as well as discuss the relationship between thiamine supplementation and demyelinating diseases in the central nervous system. Sujata Publications 2025-06-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/134 10.62896/jcarr.v2.i2.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 05-09 3048-6556 eng https://jcarr.in/index.php/files/article/view/134/79 https://jcarr.in/index.php/files/article/view/134/80 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/136 2025-12-15T10:07:29Z files:ART

Importance of Green Principles in Drug Discovery: Updated Review Shubham Aashiyan* Km Preeti Deepak Kushwaha Neelam Singh Vivek Kumar Kushwaha Triloki Prasad Green chemistry, Environment, Green methods, Reduce waste, High yield. Green chemistry provides a framework for chemists, pharmacists, medicinal chemists and chemical engineers to design processes, protocols and synthetic methodologies to make their contribution to the broad spectrum of global sustainability. Green synthetic conditions, especially catalysis, are the pillar of green chemistry. Green chemistry principles help synthetic chemists overcome the problems of conventional synthesis, such as slow reaction rates, unhealthy solvents and catalysts and the long duration of reaction completion time, and envision solutions by developing environmentally benign catalysts, green solvents, use of microwave and ultrasonic radiations, solvent free, grinding and chemo-mechanical approaches. Sujata Publications 2025-06-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/136 10.62896/jcarr.v2.i2.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 10-13 3048-6556 eng https://jcarr.in/index.php/files/article/view/136/81 https://jcarr.in/index.php/files/article/view/136/82 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/137 2025-12-15T10:07:29Z files:ART

Potential Drug-Drug Interactions and Adverse Drug Reactions associated with Azithromycin used in the treatment of COVID-19 Infected Patients: A Drug Information Resources-Based Review Mohammad Daud Ali Munfis Patel Nuzhat Banu Md. Sarfaraz Alam Latha Kannan Md. Salahuddin Ansari Sarfaraz Ahmad* COVID 19, Micromedex®, Azithromycin, Drug-Drug interactions, Cardiac function The end of 2019 became the most remarkable one in human history with the start of an epidemic in Wuhan city of China. The severe respiratory syndrome caused by COVID-19 (named as SARS-CoV-2) created a crisis for public well-being internationally, and the WHO had to declare it a pandemic by March 12, 2020. Many trials are being carried out to check the efficiency and safety of the drugs and treatments. Some of the commonly used drugs are LopinavirRitonavir, Tocilizumab, azithromycin, Hydroxychloroquine, and Convalescent plasma. The drug Hydroxychloroquine, which gave good results earlier, now has restricted use due to a lack of usefulness, but the usage of azithromycin is continued. Micromedex® drug Interaction tool analysis to evaluate and identify Azithromycinrelated possible Drug Drug interactions. Azithromycin tablet highlights the warnings of possible health hazards associated with the administration of Azithromycin along with Precautions in certain co-morbidities and contraindicated patients. The complications with the use of Azithromycin are mostly associated with cardiac functioning; therefore, while selecting of drug, patient ECG should be ruled out before initiation of therapy. A major proportion of patients are asymptomatic; therefore, blind use of Azithromycin should be prohibited. Considering DDIs and ADRs associated with Azithromycin use, it should be used under clinical care with emphasizing proper screening in cardiovascular comorbid patients and those with liver dysfunction. Sujata Publications 2025-06-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/137 10.62896/jcarr.v2.i2.04 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 14-23 3048-6556 eng https://jcarr.in/index.php/files/article/view/137/83 https://jcarr.in/index.php/files/article/view/137/84 https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/139 2025-12-15T10:07:29Z files:ART

Continuous Glucose Monitoring during Radiological Imaging Rashmi Singh*, Surya Prakash, Deepak Katiyar, Rahul Gangwar Continuous Glucose Monitoring; Radiological Imaging; Diabetes; PET; CT; MRI; Hypoglycemia; Diagnostic Accuracy. Continuous Glucose Monitoring (CGM) has revolutionized the administration of diabetes, permitting for real-time following of glucose levels all through the day. As of late, the integration of CGM frameworks amid radiological imaging methods has picked up consideration as a pivotal improvement for diabetic patients experiencing demonstrative tests. Customarily, imaging strategies such as CT looks, MRIs, and PET checks require fasting, which can altogether influence the blood glucose levels of diabetic patients, driving to complications. By empowering real-time glucose observing amid these imaging methods, CGM frameworks offer the potential to improve the security and consolation of diabetic patients, progress the quality of demonstrative imaging, and give more personalized care. This investigate article investigates the mechanical headways in CGM frameworks, their application amid radiological imaging, and the potential benefits for diabetic patients. It analyzes the integration of CGM sensors with imaging conventions, examines clinical trials, and highlights the potential challenges. Moreover, it looks at how nonstop observing can help in minimizing dangers such as hypoglycemia, hyperglycemia, and changes which will meddled with the imaging handle. By empowering healthcare experts to mediate instantly, CGM innovation offers a modern measurement to diabetes administration, giving superior results for patients experiencing imaging methods. This paper examines the clinical importance of CGM in radiological imaging and investigates future opportunities for broader integration within the therapeutic field. Sujata Publications 2025-06-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/139 10.62896/jcarr.v2.i2.05 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 24-26 3048-6556 eng https://jcarr.in/index.php/files/article/view/139/85 https://jcarr.in/index.php/files/article/view/139/86 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/140 2025-12-15T10:07:29Z files:ART

Antimicrobial and In- Vivo Antiacne Activity of Ethanolic Extract of Notonia Grandiflora Leaves Upendra Kumar*, Dr. Satkar Prasad, Dr. Sailesh Kumar Ghatuary Notonia grandiflora, antiacne activity, antimicrobial activity, phytochemicals, ethanolic extract, Propionibacterium acnes, flavonoids, inflammation, in vivo model, herbal medicine. The present study investigated the antimicrobial and in vivo antiacne activities of the ethanolic extract of Notonia grandiflora leaves. Phytochemical analysis revealed the presence of several bioactive compounds including alkaloids, flavonoids, phenols, tannins, saponins, and glycosides, which are known for their pharmacological properties. The antimicrobial potential was assessed against Propionibacterium acnes and Klebsiella pneumoniae using the agar well diffusion method, demonstrating dose-dependent inhibition, with the highest zone of inhibition observed at 100 mg/ml. In vivo antiacne activity was evaluated in rats using a P. acnes-induced acne model. The extract showed a significant reduction in lesion thickness in a dose-dependent manner, comparable to the standard drug Clindamycin. The findings suggest that the ethanolic extract of Notonia grandiflora possesses promising antiacne potential, likely due to its antimicrobial and anti-inflammatory properties. This supports its potential application as a natural alternative for acne treatment. Sujata Publications 2025-06-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/140 10.62896/jcarr.v2.i2.06 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 2, April-June 2025; 27-32 3048-6556 eng https://jcarr.in/index.php/files/article/view/140/87 https://jcarr.in/index.php/files/article/view/140/88 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/143 2025-11-22T11:24:54Z files:ART

Green Chemistry New Approach in Organic Synthesis: A Sustainable Approach Km Shiksha, Priti Sharma, Vikas Kardam, Rubina, Piyush Gautam, Rajkumar, Titu, Keshav Sharma, Arif, Triloki Prasad Green chemistry, sustainable chemistry, toxic chemicals, Organic synthesis. An overview of the applicability of 12 green chemistry principles is provided in this work. The production of chemical products and processes that minimize the use and production of harmful materials is referred to as "green chemistry." There are a number of main ways to accomplish the environmental protection objectives of green chemistry. Bio-catalysis, the use of alternative repeatable raw materials (biomass), alternative reaction solutions (such as ionic liquids, supercritical fluids, and water), alternative reaction conditions (microwave activation), and new photocatalytic reactions are just a few examples. Furthermore, the primary objective of green chemistry is to preserve Earth's natural resources without utilizing harmful materials. One of the primary objectives of green chemistry is the reduction of pollution and harmful waste through alterations in consumption and production patterns. Sujata Publications 2025-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/143 10.62896/jcarr.i2.v4.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 4, Oct-Dec, 2025; 01-06 3048-6556 eng https://jcarr.in/index.php/files/article/view/143/89 https://jcarr.in/index.php/files/article/view/143/90 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/144 2025-11-22T11:24:54Z files:ART

Understanding Retnitis Pigmentosa through Ayurgenomics Divyasri R N*, Sathisha Shankara B, Kavyashree R N Retinitis Pigmentosa, Ayurgenomics, Prakriti, Ayurveda, Personalized Medicine, Photoreceptor Degeneration. Retinitis pigmentosa (RP) is a genetically diverse set of inherited retinal dystrophies characterized by progressive photoreceptor degradation, which causes night blindness, peripheral vision loss, and eventual blindness. Despite improvements in molecular genetics, conclusive cures are still lacking. Ayurgenomics, an emerging subject that combines Ayurveda's Prakriti-based constitutional framework with current genomics, offers a fresh way to determining individual vulnerability and therapeutic solutions. This review examines Retinitis Pigmentosa through the lens of Ayurgenomics, comparing traditional Ayurvedic descriptions of hereditary and degenerative ocular illnesses to genetic insights and proposing integrative approaches for early detection, risk assessment, and individualized care. Sujata Publications 2025-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/144 10.62896/jcarr.v2.i4.02 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 4, Oct-Dec, 2025; 07-09 3048-6556 eng https://jcarr.in/index.php/files/article/view/144/91 https://jcarr.in/index.php/files/article/view/144/92 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/145 2025-11-22T11:39:08Z files:ART

Formulation and Evaluation of Fast Dissolving Herbal Tablets of Cyathea Gigantea for Management of Diabetes Priyanka Kumari, Sunil Shah, B. K. Dubey, Deepak Kumar Basedia, Prabhat Kumar Jain Cyathea gigantea, herbal tablets, fast-dissolving, diabetes management, phytochemical analysis, phenolic compounds, flavonoids, drug release kinetics. The present study aimed at the formulation and evaluation of fast-dissolving herbal tablets of Cyathea gigantea for the management of diabetes. Various extracts of Cyathea gigantea, including chloroform, acetone, ethanolic, and aqueous extracts, were prepared and analyzed for yield and phytochemical constituents. The ethanolic and aqueous extracts exhibited the highest concentrations of phenolic compounds and flavonoids, which are known for their antioxidant and anti-diabetic properties. Tablets were formulated using these extracts, and pre- and post-compression parameters were evaluated. The tablets showed good flow properties, acceptable hardness, and low friability. The drug content uniformity was found to be satisfactory across all formulations. Notably, the disintegration time of the tablets varied, with formulation F4 showing the fastest disintegration time of 36 seconds. The release kinetics of F4 followed the Higuchi model (r² = 0.9975), indicating a controlled release pattern. The results suggest that Cyathea gigantea fast-dissolving tablets, particularly formulation F4, may offer a promising alternative for diabetes management, combining ease of use and effective drug release. Sujata Publications 2025-11-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/145 10.62896/jcarr.v2.i4.03 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 2, Number 4, Oct-Dec, 2025; 10-19 3048-6556 eng https://jcarr.in/index.php/files/article/view/145/93 https://jcarr.in/index.php/files/article/view/145/94 Copyright (c) 2025 Sujata Publications https://creativecommons.org/licenses/by-nc/4.0

oai:ojs2.jcarr.in:article/149 2026-01-15T13:34:30Z files:ART

Role of Uttara Basti in the Management of Obstructive Uropathy Due to Urethral Stricture: A Case Report Vidya G Mohan Obstructive uropathy, chronic urological condition, Vata dosha Obstructive uropathy due to urethral stricture is a chronic urological condition that results in impaired urinary flow, recurrent lower urinary tract symptoms, and secondary inflammatory changes such as cystitis. Despite advances in surgical management, recurrence and functional obstruction remain common. In Ayurveda, similar clinical presentations are described under Mootraghata, primarily caused by vitiation of Vata dosha leading to obstruction of Mutravaha srotas. This case report describes the conservative management of obstructive uropathy secondary to urethral stricture in a young male patient using Sahacharadi Taila Uttara Basti along with internal Ayurvedic medications. Clinical improvement was objectively assessed using the International Prostate Symptom Score (IPSS) before treatment and after two weeks. Radiological evaluation using retrograde urethrogram (RGU) confirmed urethral narrowing with cystitis and diverticular formation. Significant symptomatic improvement and reduction in IPSS score were observed following treatment. This case suggests that Ayurvedic management may be beneficial in selected cases of obstructive uropathy by addressing both functional obstruction and associated inflammation. Sujata Publications 2026-01-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf application/pdf https://jcarr.in/index.php/files/article/view/149 10.62896/jcarr.v3.i1.01 Journal of Clinical Advances and Research Reviews; JCARR: Vol. 3, Issue 1, January-March, 2026; 01-04 3048-6556 eng https://jcarr.in/index.php/files/article/view/149/97 https://jcarr.in/index.php/files/article/view/149/98 Copyright (c) 2026 Journal of Clinical Advances and Research Reviews https://creativecommons.org/licenses/by-nc/4.0