Evidence-Based Management of Recurrent UTIs: From Diagnosis to Prevention

Abstract

Recurrent urinary tract infections (UTIs) result from a complex interaction between bacterial virulence and host factors, making effective diagnosis and treatment crucial. Cultures are essential for confirming recurrent UTIs, allowing for accurate diagnosis and the monitoring of antibiotic resistance patterns, which benefits both the individual patient and the broader community. Initial therapy for acute infections should follow the guidelines established by the Infectious Diseases Society of America (IDSA), considering regional antimicrobial resistance patterns to ensure effective treatment. Prevention strategies vary based on patient demographics and risk factors. Younger individuals may reduce their risk by avoiding spermicides, which can disrupt the vaginal microbiome, and by taking cranberry supplements, which may prevent bacterial adhesion to the bladder lining.

In older patients, the use of topical oestrogen can help maintain urogenital mucosa integrity, while strategies like ensuring complete bladder emptying and staying well-hydrated are also important in preventing infections. For patients prone to recurrent infections, long-term antibiotic prophylaxis may be considered. This approach can reduce the frequency of UTIs, although it must be carefully tailored to avoid the development of antibiotic resistance. Overall, a combination of tailored acute treatment and preventive measures offers the best approach for managing recurrent UTIs and minimizing their impact on patient health and public health.