Antimicrobial and In- Vivo Antiacne Activity of Ethanolic Extract of Notonia Grandiflora Leaves

Abstract

The present study investigated the antimicrobial and in vivo antiacne activities of the ethanolic extract of Notonia grandiflora leaves. Phytochemical analysis revealed the presence of several bioactive compounds including alkaloids, flavonoids, phenols, tannins, saponins, and glycosides, which are known for their pharmacological properties. The antimicrobial potential was assessed against Propionibacterium acnes and Klebsiella pneumoniae using the agar well diffusion method, demonstrating dose-dependent inhibition, with the highest zone of inhibition observed at 100 mg/ml. In vivo antiacne activity was evaluated in rats using a P. acnes-induced acne model. The extract showed a significant reduction in lesion thickness in a dose-dependent manner, comparable to the standard drug Clindamycin. The findings suggest that the ethanolic extract of Notonia grandiflora possesses promising antiacne potential, likely due to its antimicrobial and anti-inflammatory properties. This supports its potential application as a natural alternative for acne treatment.