Formulation and Evaluation of Fast Dissolving Herbal Tablets of Cyathea Gigantea for Management of Diabetes

Abstract

The present study aimed at the formulation and evaluation of fast-dissolving herbal tablets of Cyathea gigantea for the management of diabetes. Various extracts of Cyathea gigantea, including chloroform, acetone, ethanolic, and aqueous extracts, were prepared and analyzed for yield and phytochemical constituents. The ethanolic and aqueous extracts exhibited the highest concentrations of phenolic compounds and flavonoids, which are known for their antioxidant and anti-diabetic properties. Tablets were formulated using these extracts, and pre- and post-compression parameters were evaluated. The tablets showed good flow properties, acceptable hardness, and low friability. The drug content uniformity was found to be satisfactory across all formulations. Notably, the disintegration time of the tablets varied, with formulation F4 showing the fastest disintegration time of 36 seconds. The release kinetics of F4 followed the Higuchi model (r² = 0.9975), indicating a controlled release pattern. The results suggest that Cyathea gigantea fast-dissolving tablets, particularly formulation F4, may offer a promising alternative for diabetes management, combining ease of use and effective drug release.